Author

August J. John

Mayo ClinicORCID 0000-0003-4615-9474Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Abedalrahman Jomaa· 1 shared Adam D. BassiD· 1 shared Archit Bajaj· 1 shared Ateka Saleh· 1 shared Brandon J. CoombesiD· 1 shared Ching Man WaiiD· 1 shared Duan LiuiD· 1 shared Enci Ding· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Abedalrahman Jomaa

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Lestaurtinib's antineoplastic activity converges on JAK/STAT signaling to inhibit advanced forms of therapy resistant ovarian cancer

Esther P. B. Rodman, Michael J. Emch, Xiaonan Hou, Archit Bajaj, Nicole A Pearson, August J. John, Yamillie Ortiz, Adam D. Bass, Saloni Singh, Gustavo Baldassarre, Scott H. Kaufmann, S. John Weroha, John R. Hawse

This study identifies lestaurtinib as a potent inhibitor of ovarian cancer, effective against resistant models, by targeting JAK/STAT signaling and synergizing with standard therapies.

npj Precision Oncology · Jul 11, 2025Peer-reviewedCancer Biology

Alcohol Use Disorder Associated Gene FNDC4 Alters Glutamatergic and GABAergic Neurogenesis

Xiujuan Zhu, August J. John, Li Wang, Sooan Kim, Enci Ding, Ateka Saleh, Irene Marín-Goñi, Abedalrahman Jomaa, Huanyao Gao, Ching Man Wai, Irene Moon, Brandon J. Coombes, Tony M. Kerr, Nobuyoshi Suto, Liewei Wang, , Duan Liu

The paper identifies FNDC4 as a gene associated with alcohol use disorder through GWAS and shows its role in regulating neurogenesis via alternative splicing and CRISPR/Cas9 experiments.

bioRxiv · May 15, 2025 · PreprintGenomics