Author

S. John Weroha

Mayo ClinicORCID 0000-0002-7130-7259Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 5 Approach:statistical model· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2

Frequent Co-Authors

Scott H. KaufmanniD· 3 shared Xiaonan HouiD· 3 shared Akhilesh PandeyiD· 2 shared Alexandre Gaspar‐MaiaiD· 2 shared Megan L. RittingiD· 2 shared Mihai Gabriel DumbravaiD· 2 shared Nagarajan KannaniD· 2 shared Syed Mohammed Musheer AalamiD· 2 shared

Activity by Year

2025-2025 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

Scott H. KaufmannORCID

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Author profile →

5 papers

Recent·Most cited

Proteomic Analysis of PTEN-Deficient Cells Reveals Src-Mediated Upregulation of EphA2 and Therapeutic Potential of Dual Inhibition

Qiong Wang, Xiangyi Kong, Hongming Song, Li Wang, Lingrui Li, Xiaonan Hou, Santosh Renuse, Muhammad Saddiq Zahari, Ran Cheng, Mahmood Khan, Jidong Wang, Kiran Kumar Mangalaparthi, Lin Fang, Tamara Levin Lotan, Ben Ho Park, , Xinyan Wu

This study identifies Src-mediated upregulation of EphA2 in PTEN-deficient cells and shows that combined AKT and Src inhibition synergistically suppresses tumor growth.

Molecular & Cellular Proteomics · Oct 22, 2025Peer-reviewedCancer Biology

A Rare Multipotent Peg-like Epithelial Cell is a Candidate Cell-of-Origin for High-Grade Serous Ovarian Cancer

Megan L. Ritting, Wenmei Yang, Syed Mohammed Musheer Aalam, Hui Zhao, Feng Liang, Jianning Song, Mihai Gabriel Dumbrava, Wazim Mohammed Ismail, Dong‐Gi Mun, Chunling Hu, Opalina Roy, Keyur Chaludiya, Geng Xian Shi, Daphne Norma Crasta, Kenneth Schaufelberger, , Nagarajan Kannan

The paper identifies a rare multipotent epithelial cell in the fallopian tube as a potential cell-of-origin for high-grade serous ovarian cancer using multi-omic profiling and organoid models.

bioRxiv · Sep 23, 2025 · PreprintCancer Biology

Lestaurtinib's antineoplastic activity converges on JAK/STAT signaling to inhibit advanced forms of therapy resistant ovarian cancer

Esther P. B. Rodman, Michael J. Emch, Xiaonan Hou, Archit Bajaj, Nicole A Pearson, August J. John, Yamillie Ortiz, Adam D. Bass, Saloni Singh, Gustavo Baldassarre, Scott H. Kaufmann, S. John Weroha, John R. Hawse

This study identifies lestaurtinib as a potent inhibitor of ovarian cancer, effective against resistant models, by targeting JAK/STAT signaling and synergizing with standard therapies.

npj Precision Oncology · Jul 11, 2025Peer-reviewedCancer Biology

Functional impact of the hyperduplication genomophenotype in high copy number endometrial cancer

Angela B. Florio, James B. Smadbeck, Sarah H. Johnson, Wan‐Hsin Lin, Dorsay Sadeghian, Sotiris Sotiriou, Rebeca Salvatori, Ryan W. Feathers, Taylor Berry, Lindsey Kinsella, Faye R. Harris, Alexa McCune, Stephen J. Murphy, Mohamed F. Ali, Abdulmohammad Pezeshki, , George Vasmatzis

The paper investigates the functional impact of the HyperDuplication GenomoPhenotype in high copy number endometrial cancer, showing it enhances tumor fitness and therapy resistance through coordinated duplication of oncogenes.

iScience · Jun 7, 2025Peer-reviewedGenomics

Single cell resolution of an epigenetic signature of persister tumor cell

Mihai Gabriel Dumbrava, Wazim Mohammed Ismail, Letícia Sandoval, Amelia Mazzone, Syed Mohammed Musheer Aalam, Megan L. Ritting, Xiaonan Hou, Yiwen Xie, Shariska Petersen Harrington, Scott H. Kaufmann, Nagarajan Kannan, S. John Weroha, Alexandre Gaspar‐Maia

The paper identifies an epigenetic signature associated with persister tumor cells in ovarian cancer that correlates with chemotherapy resistance and defines the persister state.

bioRxiv · Apr 16, 2025 · PreprintGenomics