Ching Man Wai

Binary-SPA: A Reference-Free Method for Cell Annotation in High-Resolution Spatial Transcriptomics

Binary-SPA improves cell type annotation in spatial transcriptomics by using a two-stage approach without requiring external reference data.

Multi-site Assessment of Methods for Cell Preservation Upstream of Single Cell RNA Sequencing

This study evaluates three cell preservation methods for scRNA-seq across multiple sites, showing concordant cell type results but platform-specific gene expression differences and better granulocyte retention with preservation methods.

Stromal Gasdermin D-mediated Pyroptosis Drives Maladaptive CD4⁺ T-cell Remodeling in Tet2-Deficient Hematopoiesis

This study shows that stromal gasdermin D-mediated pyroptosis promotes CD4⁺ T-cell remodeling in Tet2-deficient hematopoiesis by creating a feedback loop between stromal cells and immune cells.

Machine Learning Identifies Distinct Treg-Mediated Remodeling in HFpEF Hearts Treated with Neonatal Mesenchymal Stem Cells and Their Secretome

This study uses machine learning to identify Treg-mediated mechanisms by which nMSCs and their secretome improve diastolic function in HFpEF.

Alcohol Use Disorder Associated Gene FNDC4 Alters Glutamatergic and GABAergic Neurogenesis

The paper identifies FNDC4 as a gene associated with alcohol use disorder through GWAS and shows its role in regulating neurogenesis via alternative splicing and CRISPR/Cas9 experiments.

Genomic footprints of repeated evolution of CAM photosynthesis in tillandsioid bromeliads

This study investigates the genomic changes associated with the evolution of CAM photosynthesis in Tillandsioid bromeliads using phylogenomic and transcriptomic analyses.