Huanyao Gao

Convergent and divergent phenotypic impacts of estradiol on neurodevelopmental disorder risk genes

The paper evaluates estradiol's effects on ASD/NDD genes using human neurons and zebrafish, finding both convergent transcriptomic effects and gene-specific cellular and behavioral rescue.

Mitochondrial Complex I Modulator Restores Network Resilience in Advanced Alzheimer's Disease Through Metabolic Reprogramming

The paper shows that modulating mitochondrial complex I in advanced Alzheimer's disease improves metabolic resilience through coordinated mitochondrial and lipid metabolism.

Ndufs4 knockout induces transcriptomic signatures of Alzheimer's Diseases that are partially reversed by mitochondrial complex I inhibitor

This study shows that reducing mitochondrial complex I activity in mice induces AD-like transcriptomic changes, which are partially reversed by a complex I inhibitor.

Alcohol Use Disorder Associated Gene FNDC4 Alters Glutamatergic and GABAergic Neurogenesis

The paper identifies FNDC4 as a gene associated with alcohol use disorder through GWAS and shows its role in regulating neurogenesis via alternative splicing and CRISPR/Cas9 experiments.

Dynamic convergence of neurodevelopmental disorder risk genes across neurodevelopment

This study identifies convergent biological pathways in mature neurons affected by neurodevelopmental disorder risk genes and shows drug candidates can ameliorate behavioral phenotypes.

Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common Diseases

The paper shows glucocorticoid exposure reveals the function of non-coding genetic variants linked to disease risk by influencing gene expression in relevant biological processes.

Identification of transcriptional network disruptions in drug-resistant prostate cancer with TraRe

The paper identifies transcriptional network disruptions in drug-resistant prostate cancer using TraRe, uncovering key regulatory modules and transcription factors associated with resistance.

Glucocorticoids Mediate Transcriptome-wide Alternative Polyadenylation: Mechanisms and Functional Implications

This study shows glucocorticoids regulate alternative polyadenylation in human B-lymphoblastoid cells, affecting gene function and immune-related pathways.