Author
Columbia University Irving Medical CenterORCID 0000-0003-4622-4627Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Hiroyuki Kojima, Charlotte R. Wayne, Luis F. Somarribas Patterson…·Ekaterina V. Vinogradova
In chronically stimulated human T cells, suppressed oxidative metabolism and nucleotide loss accompany MAP2K4 activation. Inhibiting MAP2K4 (with the MKK4/7 inhibitor BSJ-04-122) restored tumor-cell killing in vitro.
Tiffany Zhang, Henry Sanford, Railia R Gabbasova…·Ekaterina V. Vinogradova
The paper uses multi-omics approaches to study post-translational changes in macrophages during activation, identifying endosomal mRNA transport as a target of inflammation.
Kaja Plucińska, Charlotte R. Wayne, Henry Sanford…·Ekaterina V. Vinogradova
A Cre-dependent ER-targeted TurboID knock-in mouse enables cell type-specific secretory proteomics, mapping adipocyte and hepatocyte responses to fasting, LPS and obesity, with B cells profiled at baseline.
Charlotte R. Wayne, Uğur Akcan, Travis E. Faust…·Dritan Agalliu
This study identifies IL-17A-IL-17RA signaling in microglia as a critical driver of BBB dysfunction after GAS infections using single-cell RNA sequencing and spatial transcriptomics.
Charlotte R. Wayne, Luca Bremner, Travis E. Faust…·Dritan Agalliu
The paper investigates how Th17 cytokines influence microglial and blood-brain barrier responses during post-infectious encephalitis using single-cell RNA sequencing and spatial transcriptomics.