Travis E. Faust

Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in post-streptococcal encephalitis

This study identifies IL-17A-IL-17RA signaling in microglia as a critical driver of BBB dysfunction after GAS infections using single-cell RNA sequencing and spatial transcriptomics.

Astrocyte redox imbalance underlies prelimbic neuronal hypoactivity and affective behavior in epilepsy

This study shows that astrocyte redox imbalance causes neuronal hypoactivity and affective behaviors in epilepsy, distinct from seizure mechanisms.

Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling

This study shows microglia instruct astrocyte-synapse interactions via Wnt signaling, enabling microglia to remove synapses during activity-dependent remodeling.

A comparative analysis of microglial inducible Cre lines

This study evaluates four microglial inducible Cre lines, showing differences in recombination efficiency and spontaneous recombination, and provides best practices for measuring these in microglia.

Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis

The paper investigates how Th17 cytokines influence microglial and blood-brain barrier responses during post-infectious encephalitis using single-cell RNA sequencing and spatial transcriptomics.

Microglial phagocytosis dysfunction during stroke is prevented by rapamycin

This study shows that microglial phagocytosis dysfunction during stroke is prevented by rapamycin, highlighting its potential as a therapeutic target.