Dorothy P. Schafer

The paper identifies aggrecan as an extracellular matrix protein that stabilizes fear memories by altering neuronal excitability in the hippocampal dentate gyrus.

The paper identifies myelin basic protein (MBP) as an RNA chaperone that facilitates microglial nuclear import of myelin RNA, with implications for multiple sclerosis pathology.

This study identifies IL-17A-IL-17RA signaling in microglia as a critical driver of BBB dysfunction after GAS infections using single-cell RNA sequencing and spatial transcriptomics.

This study creates a multi-modal atlas of choroid plexus pathology across aging and Alzheimer's disease, identifying fibrosis, calcification, and macrophage abnormalities as key features.

The paper identifies cell-type and disease-specific circadian gene expression changes in glial cells under amyloid pathology or aging in mice.

This study shows microglia instruct astrocyte-synapse interactions via Wnt signaling, enabling microglia to remove synapses during activity-dependent remodeling.

This study shows that senescent microglia impair remyelination in young mice but not aged mice, with CCL11 in SASP inhibiting oligodendrocyte maturation.

The paper identifies spatiotemporal diversity of primate brain cells during white matter inflammatory demyelination using a cross-modality approach to inform lesion detection and management in multiple sclerosis.

The paper identifies a GABAergic neuronal ensemble in the medial orbitofrontal cortex that suppresses binge alcohol drinking by projecting to the mediodorsal thalamus.

This study shows that ALS-linked PFN1 mutations impair vesicular degradation in iPSC-derived microglia by disrupting autophagy, which can be mitigated by Rapamycin.

The paper identifies lipofuscin-like autofluorescence in microglia that can interfere with detecting synaptic material and proposes a method to quench this autofluorescence in multiple species.

This study evaluates four microglial inducible Cre lines, showing differences in recombination efficiency and spontaneous recombination, and provides best practices for measuring these in microglia.

The paper investigates how Th17 cytokines influence microglial and blood-brain barrier responses during post-infectious encephalitis using single-cell RNA sequencing and spatial transcriptomics.

This study shows that microglial phagocytosis dysfunction during stroke is prevented by rapamycin, highlighting its potential as a therapeutic target.

The paper identifies non-coding variants in the IL18RAP 3'UTR that reduce ALS risk by modulating neuro-inflammation through NF-κB signaling in microglia.

This paper analyzes juxtavascular microglia dynamics in mice and humans, showing their developmental migration along vessels and stabilization as astrocyte endfeet ensheath the vasculature.

This study identifies synapse loss and microglial synaptic engulfment in MS models and demonstrates that targeted complement inhibition prevents synapse loss and visual dysfunction.

This study shows that sensory lesioning causes microglia to eliminate synapses through ADAM10 and fractalkine signaling, revealing a neuron-to-microglia pathway for synaptic remodeling.