Author

Hiroyuki Kojima

Rockefeller UniversityORCID 0000-0002-1621-9352Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Beatrice D. ZhangiD· 2 shared Charlotte R. WayneiD· 2 shared Ekaterina V. VinogradovaiD· 2 shared Henry SanfordiD· 2 shared Omar Ibrahim Abdel-WahabiD· 2 shared Tiffany L. ZhangiD· 2 shared A. Ari HakimiiD· 1 shared Anne E. van VlimmereniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

Beatrice D. ZhangORCID

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2 papers

Recent·Most cited

Cysteine reactivity profiling links metabolic rewiring to the dysfunctional human T cell proteome.

Hiroyuki Kojima, Charlotte R. Wayne, Luis F. Somarribas Patterson, Henry Sanford, Tzu-Jou Chen, Ya-Hui Lin, Joshua David Schoenfeld, Lisa H.F. McGary, Yanting Chen, Korbinian Nepomuk Kropp, Beatrice D. Zhang, Jahan A. Rahman, Tiffany L. Zhang, Nathalie Ropek, Cameron G. Roberts, , Ekaterina V. Vinogradova

In chronically stimulated human T cells, suppressed oxidative metabolism and nucleotide loss accompany MAP2K4 activation. Inhibiting MAP2K4 (with the MKK4/7 inhibitor BSJ-04-122) restored tumor-cell killing in vitro.

bioRxiv · Oct 2, 2026 · PreprintImmunology✦ In-depth digest

Chemical proteomics reveals post-translational remodeling of endosomal pathways during macrophage activation.

Tiffany Zhang, Henry Sanford, Railia R Gabbasova, Anne E. van Vlimmeren, Yannis L. Kalaidzidis, Hiroyuki Kojima, Charlotte R. Wayne, Jeetayu Biswas, Priyam Banerjee, Beatrice D. Zhang, Omar Ibrahim Abdel-Wahab, Marino Zerial, Ekaterina V. Vinogradova

The paper uses multi-omics approaches to study post-translational changes in macrophages during activation, identifying endosomal mRNA transport as a target of inflammation.

bioRxiv · Oct 1, 2026 · PreprintImmunology