J.A. Brannigan

A pH-dependent protein kinase cascade regulates divergent differentiation of Leishmania in the sand fly.

This study identifies a pH-dependent kinase cascade in Leishmania that regulates differentiation into infectious stages, revealing key pathways for acid adaptation and transmission.

Chemical genetics reveals Leishmania KKT2 and CRK9 kinase activity is required for cell cycle progression

This study identifies KKT2 and CRK9 as essential kinases for Leishmania cell cycle progression using chemical genetics and CRISPR-Cas9.

The mitotic spindle kinase MSK co-ordinates segregation of the nucleus and kinetoplast in Leishmania mexicana

This study identifies MSK as a kinase essential for coordinating nucleus and kinetoplast segregation in Leishmania mexicana, showing its role in mitotic spindle function and cell survival.

Structure and Activity of the Essential UCH Family Deubiquitinase DUB16 from Leishmania donovani

This study characterizes DUB16, an essential UCH family deubiquitinase in Leishmania donovani, showing its structure, activity, and potential as a drug target.