Jeremy Charles Mottram

This study identifies a pH-dependent kinase cascade in Leishmania that regulates differentiation into infectious stages, revealing key pathways for acid adaptation and transmission.

A 3D-printed OpenFlexure Microscope adapted for humid incubators, with relocated electronics, ASA printing and 22 Ω current-limiting resistors, records 48-hour label-free docetaxel responses that CellPhe can analyse.

This study identifies KKT2 and CRK9 as essential kinases for Leishmania cell cycle progression using chemical genetics and CRISPR-Cas9.

This study maps the Leishmania ubiquitinome and identifies DUB2 as a key regulator of differentiation by modulating ubiquitination of proteins involved in cell motility and metabolism.

This study uses CRISPR-Cas9 to edit phosphosite codons in kinetochore proteins of Leishmania mexicana, finding no growth defects in phosphosite mutants.

This study maps parasite dissemination patterns in visceral leishmaniasis using a barcoded library and ecological analysis, revealing bi-directional highways and super-seeder tissues.

This paper identifies and validates cell-permeable inhibitors of Leishmania mexicana CLK1 using a BRET-based assay, showing WZ8040 effectively targets CLK1 with minimal host toxicity.

This study identifies MSK as a kinase essential for coordinating nucleus and kinetoplast segregation in Leishmania mexicana, showing its role in mitotic spindle function and cell survival.

This study shows that flagellum assembly and BBSome integrity are essential for Leishmania mexicana pathogenicity, while flagellar motility is not required for infection.

This study characterizes DUB16, an essential UCH family deubiquitinase in Leishmania donovani, showing its structure, activity, and potential as a drug target.

The paper identifies essential membrane transporters for Leishmania survival through a CRISPR-Cas9 gene deletion screen, finding that V-ATPase is critical for amastigote survival despite being dispensable for promastigote growth.

This study shows that the Leishmania donovani species complex dispersed globally within the last 2,000 years, aligning with human migration and colonization.

This study identifies key ubiquitination enzymes essential for Leishmania differentiation and infection, showing that UBC2 and UEV1 form a complex critical for ubiquitination activity.

Tapestry validates and edits small eukaryotic genome assemblies using long reads by generating an interactive report for contig analysis.

This study shows that ATR kinase in Trypanosoma brucei is essential for DNA damage signaling and controls monoallelic VSG expression during antigenic variation.