Tovah E. Markowitz

This study identifies NONO as a host factor that epigenetically regulates DPP4 expression, facilitating MERS-CoV replication by modulating histone modifications at the DPP4 locus.

This study shows that BORIS, a CTCF paralog, promotes ovarian cancer by altering 3D genome organization and transcriptional programs through chromatin remodeling.

This study identifies NONO as a critical facilitator of antiviral innate immune response by promoting chromatin accessibility and IFN-I/ISG expression.

This study shows HPV31 genomes associate with active host chromatin regions, linking viral persistence to transcriptional activity and integration sites in cervical cancers.

This study identifies condensin as a regulator of meiotic chromosome axis remodeling near crossover sites in yeast, showing it promotes cohesin removal and affects chromosome segregation.

The paper identifies a novel PIK3R1 frameshift mutation linked to immunodeficiency and ALS, showing haploinsufficiency causes neuronal dysfunction and apoptosis.

The paper identifies sphagnum-associated fungi that produce antitubercular agents inducing thiol stress in Mycobacterium tuberculosis.

This study demonstrates that cfChIP-seq can reliably detect gene signals and tissue sources of cfDNA in physiological and heart transplant patients, identifying pathway changes in immunosuppressed individuals.

The paper identifies two pathways for meiotic chromosome axis assembly in yeast, showing cohesin-dependent and cohesin-independent mechanisms recruit axis proteins to genomic regions with high gene density.

This study investigates the roles of topoisomerases I and II in meiotic DNA breakage and chromosome remodeling in yeast, showing distinct effects of their disruption on DSB timing and chromosome structure.

The paper identifies privileged end-adjacent regions near telomeres that maintain DSBs and contribute to higher recombination rates on short chromosomes in yeast.

SNP-ChIP quantifies changes in protein binding across the genome using intra-species SNPs for normalization, improving between-sample comparisons in ChIP-seq.

This study shows that acute condensin depletion in yeast causes genome decompaction without affecting global gene expression levels.