Matteo T. Degiacomi

This study uses molecular dynamics simulations and Markov state models to compare activation mechanisms of tyrosine kinases, revealing kinase-specific conformational ensembles.

Carbonara uses SAXS data to predict alternative protein conformations, enabling more accurate MD simulations of solution-state dynamics.

The paper investigates how cardiac stress regulates Filamin C dimerisation through phosphorylation-modulated interactions with HSPB7, revealing evolutionary conservation of this mechanism.

The paper shows that dimeric subunits of sHsps are functional units for substrate capture, and that dimer stability affects chaperone efficiency.