Loss of Y chromosome in Alzheimer disease patients co-occurs with clonal hematopoiesis defined by post-zygotic point mutations outside canonical CHIP driver genes
Edyta Rychlicka-Buniowska, Daniil Sarkisyan, Monika Horbacz, Bożena Bruhn‐Olszewska, Kinga Drężek-Chyła, Mikołaj Koszyński, Hanna Davies, Ulana Juhas, Magdalena Wójcik, Alicja Klich‐Rączka, Lena Kilander, Martin Ingelsson, Karolina Bukowska-Straková, Kazimierz Węglarczyk, Maciej Siedlar, , Jan Piotr Dumanski
The paper investigates the relationship between loss of Y chromosome (LOY) and clonal hematopoiesis in Alzheimer's disease patients, finding that LOY drives myeloid clones which may accumulate additional mutations.
medRxiv · Jun 5, 2025 · PreprintGenetic & Genomic Medicine