Jan Piotr Dumanski

This study finds that cancer survivors have a higher prevalence of loss of Y chromosome in their spermatozoa compared to controls, suggesting it as a potential biomarker for genomic instability and disease risk.

The paper investigates the relationship between loss of Y chromosome (LOY) and clonal hematopoiesis in Alzheimer's disease patients, finding that LOY drives myeloid clones which may accumulate additional mutations.

This study evaluates how cold ischemia time affects gene expression in normal colon mucosa, identifying transcriptomic changes in hypoxia, EMT, and apoptosis pathways that may mimic malignancy.

The paper identifies pathogenic post-zygotic variants in normal breast tissue of poor-prognosis cancer patients, linking them to reduced survival and disease recurrence.

The paper investigates LOY in TME leukocytes, finding higher LOY frequency in Tregs and its association with immune checkpoint receptor expression.

The paper identifies multi-omic changes in immune cells from Alzheimer's disease patients with loss of Y, linking LOY to epigenetic and gene expression alterations.

The paper investigates LOY in leukocytes as a risk factor for severe COVID-19 in men, finding higher LOY levels in critical cases and associations with immune-related outcomes.

This study investigates how nucleus size affects spatial transcriptomics results and introduces CSDI to improve accuracy in analyzing consecutive tissue slices.

The paper introduces a method to estimate intra-individual changes in mosaic loss of chromosome Y (LOY) over time using standardized SNP-array data, showing higher correlation with other methods and significant individual variation.

The paper identifies genetic determinants of mosaic Y chromosome loss in blood and links it to genomic instability and non-haematological cancer risk.