Jakub Orzechowski Westholm

This study shows that influenza A virus exploits nuclear RNAi by inducing AGO2 accumulation and silencing type-I interferon genes, and that arsenic trioxide can counteract this effect.

This study presents the first paired transcriptomics and proteomics time series in Dictyostelium discoideum during multicellular development, showing that mRNA and protein levels correlate highly during growth but decrease during multicellular transition.

The paper benchmarks 16 circRNA detection tools across three human cell types, finding large differences in sensitivity but consistent precision, and recommends tool combinations for improved detection.

The paper investigates LOY in leukocytes as a risk factor for severe COVID-19 in men, finding higher LOY levels in critical cases and associations with immune-related outcomes.

This study uses single-cell and spatial transcriptomics to reveal clonal relationships and cell types in the mouse brain, showing fate-restricted progenitor cells and microglia origins.

The paper shows that most extracellular miRNAs are secreted non-vesicularly, with only <2% associated with EVs, even though EVs can stabilize miRNAs in serum.

The paper analyzes nuclear and cytosolic transcriptomes in human brain tissue, showing significant differences in RNA expression and subcellular localization patterns.

This study develops methods to detect, quantify, and visualize circRNAs in human tissues and shows their potential as diagnostic biomarkers in blood and serum.