NeurosciencebioRxivPreprint
Excessive Mechanotransduction in Sensory Neurons Causes Joint Contractures in a Mouse Model of Arthrogryposis
Shang Ma, Adrienne E. Dubin, Luis O. Romero…·Ardem Patapoutian
The paper shows that a gain-of-function PIEZO2 mutation in sensory neurons causes joint contractures in mice, and that Botox and dietary fatty acids can alleviate these defects.
DOI 10.1101/2022.06.07.495164