Kara L. Marshall

This study investigates the role of urothelial PIEZO channels in urinary function and finds that their deletion does not alter urinary behavior, suggesting PIEZO1 may influence reflexes outside the bladder.

This study identifies maladaptive Piezo1 mechanotransduction as a driver of smooth muscle aging in the gut, showing it impairs contractility and contributes to gastrointestinal dysfunction.

This study identifies PIEZO1-mediated mechanosensation as a mechanism linking aging to bladder dysfunction and proposes dietary intervention as a non-invasive strategy.

The paper shows that PIEZO2 in dorsal root ganglia neurons regulates gut motility by sensing mechanical stretch, affecting gastrointestinal transit.

The paper shows that a gain-of-function PIEZO2 mutation in sensory neurons causes joint contractures in mice, and that Botox and dietary fatty acids can alleviate these defects.

The paper uses FM 1-43 dye to identify PIEZO2-expressing neurons involved in mechanosensation, revealing its role in urethral neurons during urination.