Manuel Michaca

This study shows ATF4 interacts with EcR to both activate and repress lipid metabolism genes in Drosophila fat body under homeostasis and stress conditions.

This study identifies Atf4 as a metabolic sensor in fat tissue that regulates oogenesis and ovulation in Drosophila by modulating yolk lipoprotein synthesis and neuropeptide secretion.

The paper identifies a family of immunoglobulin superfamily genes in the cnidarian Hydractinia symbiolongicarpus, showing they are homologous to vertebrate histocompatibility genes and suggest an ancient origin of V-set domains.

The paper shows that yeast cells lacking Met15 can assimilate inorganic sulfur via Yll058w, but require exogenous methionine or hydrogen sulfide chelators to grow, challenging the traditional view of MET15 as essential for sulfur assimilation.