Jürgen Seibel

Chlamydia trachomatis deploys sphingolipids for genome organisation

This study identifies sphingolipids, specifically sphingomyelin, as key molecules involved in DNA condensation and developmental regulation in Chlamydia trachomatis.

Monitoring Sphingomyelin Biosynthesis at Nanoscale Resolution by Expansion Microscopy

This paper develops a fluorometric assay combined with expansion microscopy to visualize sphingomyelin biosynthesis at nanoscale resolution in cells.

Inter-kingdom signaling by the Legionella autoinducer LAI-1 involves the antimicrobial guanylate binding protein GBP

This study shows LAI-1, a signaling molecule from Legionella pneumophila, interacts with GBP in D. discoideum to inhibit migration and restrict bacterial growth.

Small fibre neuropathy in Fabry disease: a human-derived neuronal in vitro disease model

This study creates a neuronal in vitro model of Fabry disease to investigate small fibre neuropathy mechanisms, finding Gb3 accumulation, altered ion channel function, and mitochondrial trafficking issues.

The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2

The paper screens approved drugs for SARS-CoV-2 inhibition and finds Fluoxetine significantly inhibits the virus at low concentrations, with no effect on other viruses.