Aleena L. Patel

The paper identifies chromosomal metaloops in Drosophila brains and shows their role in organizing gene expression patterns through metadomains.

The paper investigates how cohesin-mediated loop extrusion and tethering elements contribute to enhancer-promoter interactions in Drosophila embryos using imaging, genetics, and simulations.

DAISEE improves integration of single-cell RNA-seq data from perturbation experiments, revealing ERK signaling induces novel transcriptional states in zebrafish embryos.

The paper shows ERK signaling dissolves ERF repression condensates in Ciona embryos through dynamic phase separation regulated by cell signaling.

The paper demonstrates a computational approach to integrate quantitative data from live imaging, chromatin immunoprecipitation, and optogenetic perturbation experiments to model gene repression in Drosophila embryos.