Sayantan Dutta

Modeling Dynamics of Contact Inhibition of Proliferation and Structural Order in a Confluent Epithelium

The paper models contact inhibition of proliferation in epithelial tissues by linking single-cell steric contacts to tissue-scale structural order and growth regulation.

Biophysical Design Space for Cellular Self-assembly and Dynamics

This paper presents a computational framework to study how cellular self-assembly and migration are influenced by adhesion, motility, and mechanical environment, showing optimal motility for cluster formation and two-stage adhesion effects.

Resolving the design principles that control postnatal vascular growth and scaling

The paper identifies biological principles governing postnatal aortic growth, showing it scales with the vertebral column and relies on differentiated cell proliferation rather than stem cells.

Interplay of geometry and mechanics in epithelial wound healing

This study develops a mathematical model to predict epithelial wound healing outcomes based on geometric and mechanical properties, validated through experiments on MDCK cells.

From heterogeneous datasets to predictive models of embryonic development

The paper demonstrates a computational approach to integrate quantitative data from live imaging, chromatin immunoprecipitation, and optogenetic perturbation experiments to model gene repression in Drosophila embryos.

An "individualist" model of an active genome in a developing embryo

The paper shows that active genes in Drosophila embryos are not spatially clustered but instead have distinct Pol II pools, supporting an 'individualist' model over a 'collectivist' model of gene regulation.