Zachary L. Fuller

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

The paper uses the 23andMe database to study MAP3K15's metabolic role, finding LoF carriers have delayed T2D diagnosis and reduced cholesterol.

The paper estimates the fitness costs of loss-of-function mutations in humans and relates them to disease severity and study design.

The paper explains that population genetic measures like pLI reflect selection on heterozygotes, not dominance or haploinsufficiency.

The paper analyzes the evolutionary dynamics of a segregation distorter in Drosophila pseudoobscura, finding that it persists due to suppressed recombination and epistatic selection.

The paper develops a novel pipeline for viral metagenomics in bees, identifying 127 novel viruses across multiple species and regions.

This study investigates the evolutionary forces maintaining gene arrangements in Drosophila pseudoobscura, finding that chromosomal inversions preserve multi-locus allelic combinations through indirect effects.