Douglas Brownfield

This study identifies lysosomal lipid metabolism as a driver of pancreatic cancer cell invasion through local energy production and membrane remodeling.

This paper identifies cell membrane tension as a regulator of epithelial fate transitions in the lung, showing it integrates physical and signaling cues to control AT1 and AT2 cell differentiation.

The paper identifies a molecular circuit involving C/EBP and Dlk1 that regulates fate plasticity in AT2 cells during lung development and injury.

This study identifies FGF signaling as critical for specifying and maintaining alveolar type 2 (AT2) cells, with implications for lung disease and cancer.

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

The paper reports a direct budding mechanism of alveolar development distinct from the classical model of subdivision of large air sacs.