Astrid Gillich

Wnt signaling decline drives age-related alveolar stem cell loss and impairs lung repair

This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.

Genetic correlation-guided mega-analysis of DO mice provides mechanistic insight and candidate genes for age-related pathologies

The paper uses genetic correlation analysis in DO mice to identify QTL and candidate genes linked to age-related pathologies.

Multi-immersion Oblique Plane Microscope (miOPM): A reconfigurable platform for high-resolution Light-Sheet Fluorescence Microscopy.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

Heterochronic myeloid cell replacement reveals the local brain environment as key driver of microglia aging

This study uses heterochronic myeloid cell replacement to show that the local brain environment, not intrinsic factors, drives microglia aging.

Adoptive Transfer of CD49a+ Tissue Resident memory cells reverses pulmonary fibrosis in mice.

This paper demonstrates that adoptive transfer of CD49a+ CD4+ tissue resident memory T cells reverses established pulmonary fibrosis in mice by reducing collagen and improving lung function.

Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling

This study identifies FGF signaling as critical for specifying and maintaining alveolar type 2 (AT2) cells, with implications for lung disease and cancer.

Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets

Portal integrates large-scale single-cell datasets efficiently and accurately by preserving biological variation across samples, platforms, and species.

The Tabula Sapiens: a multiple organ single cell transcriptomic atlas of humans

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.

Activated interstitial macrophages are a predominant target of viral takeover and focus of inflammation in COVID-19 initiation in human lung

This paper identifies activated interstitial macrophages as a key target of SARS-CoV-2 infection in human lung tissue, showing their role in viral takeover, inflammation, and fibrosis.

Molecular hallmarks of heterochronic parabiosis at single cell resolution

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

Alveoli form directly by budding led by a single epithelial cell

The paper reports a direct budding mechanism of alveolar development distinct from the classical model of subdivision of large air sacs.

A molecular cell atlas of the human lung from single cell RNA sequencing

The paper creates a comprehensive molecular cell atlas of the human lung using single-cell RNA sequencing, identifying 58 cell populations including 14 new types and revealing evolutionary changes in lung cell types.

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Across 1,176,683 airway and lung cells from 22 datasets, ACE2 rises with age, in males and in smokers' multiciliated cells, and is lowest in young children.