Lysosomal lipid metabolism promotes tumor cell invasion through local energetics and membrane lipid remodeling
Roseanne E. Nooren, Katherine M. Johnson, Maxwell G. Marley, Cody N. Rozeveld, Daniel F. Gibbard, Zinnarky K. Ortiz‐Correa, Mustafa Emre Gedik, Tianna Espe, Taro Hitosugi, Ian R. Lanza, Douglas Brownfield, Jun Liu, Mark A. McNiven, Gina L. Razidlo
This study identifies lysosomal lipid metabolism as a driver of pancreatic cancer cell invasion through local energy production and membrane remodeling.
bioRxiv · Jun 6, 2026 · PreprintCell Biology