Michael G. Constantinides

This study identifies MAIT cells as regulators of Treg responses in skin inflammation, showing their ability to resolve inflammation through IL-15-dependent mechanisms.

This study shows a ketogenic diet reprograms host and microbiome functions to enhance tissue regeneration through IL-17A activation and microbial riboflavin and sphingomyelinase pathways.

This study shows that early-life antibiotic use reduces MAIT cell abundance, impairing immunity to pneumonia, but this effect can be reversed by reintroducing riboflavin-synthesizing commensals.

This study identifies Vγ6 T cells as a major C. mast-responsive subset in the conjunctiva and shows that intrinsic TLR2 signaling drives metabolic reprogramming and IL-17A production.

This study shows that MAIT cells respond to extracellular and intracellular pathogens via distinct antigen-presenting cells, with type-17 MAIT cells responding to Acinetobacter baumannii and type-1 MAIT cells to Francisella tularensis.