Isaac J. Knudson

This paper demonstrates a prebiotic, nonenzymatic aminoacylation process that couples RNA and protein chirality, favoring opposite L- and D- configurations.

This paper develops a method to purify post-transcriptionally modified tRNAs from E. coli, enhancing translation yields and fidelity in cell-free systems.

This paper presents a method for high-yield, low magnesium flexizyme reactions in a water-ice eutectic phase, improving product stability and reducing Mg(II) carryover.

This study investigates how β-amino acid isomers affect ternary complex stability and translation elongation by analyzing their impact on ribosome function and EF-Tu interactions.

The paper uses atomistic simulations to identify structural criteria for substrates that can be efficiently incorporated by the E. coli ribosome.