Simon J. Williams

This study uses AlphaFold2 to analyze the structural diversity of effector proteins in rust fungi secretomes, identifying structurally related clusters and metal-binding effector candidates.

The paper identifies a novel class of resistance genes in Myrtaceae, TNJ, characterized by Jacalin domains replacing LRRs, and suggests their role in pathogen recognition.

The paper investigates the structural role of zinc coordination in the wheat rust effector AvrSr33, showing it provides a scaffold necessary for immune recognition by Sr33.

This study identifies two new resistance loci, Stb23 and Stb24, against Zymoseptoria tritici and develops KASP markers for their use in wheat breeding.

The paper determines cryo-EM structures of a plant TNL NLR, revealing its activation mechanism and NAD+ recognition, which informs engineering disease-resistant crops.

The paper identifies an AvrPstB48 effector from stripe rust fungus that triggers defence responses in wheat but does not directly correlate with disease outcomes.

This study examines the evolution and function of NIP2 paralogs in Rhynchosporium commune, showing their genomic distribution, expression during infection, and potential virulence roles.

The paper identifies a key residue in barley Mla NLR genes that enables effector binding through in vitro shuffling and yeast-two-hybrid screening.

The paper identifies that CsoSCA, a carboxysomal carbonic anhydrase in cyanobacteria, is allosterically activated by RuBP, revealing a regulatory mechanism in CO2 fixation.

The paper reports the crystal structure of AvrSr27, a Pgt effector, revealing its modular zinc-bound fold and its role in immune recognition by Sr27.