Author

Kesatebrhan Haile Asressu

University of North Carolina at Chapel HillORCID 0000-0003-4803-4739Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

Nathaniel J. MoormaniD· 3 shared Timothy Mark WillsoniD· 3 shared Anirban GhoshaliD· 2 shared Eric M. MerteniD· 2 shared John D. SearsiD· 2 shared Kenneth H. PearceiD· 2 shared Konstantin PopoviD· 2 shared Mark T. HeiseiD· 2 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Nathaniel J. MoormanORCID

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3 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedOct 10, 2024

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

Eric M. Merten, John D. Sears, Tina M. Leisner…·Kenneth H. Pearce

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

42 citationstop 1%

comparative / phylogenetic analysisdrug response / drug discovery

𝕏 PostBluesky

Cell BiologyJournal of Medicinal ChemistryPeer-reviewedSep 5, 2024

Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Anti-alphavirus Activity

Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain…·Timothy Mark Willson

The paper identifies potent covalent inhibitors of Chikungunya nsP2 protease and establishes structure-activity relationships to guide inhibitor design.

30 citationstop 1%

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Cell BiologyPharmaceuticalsPeer-reviewedFeb 27, 2024

Synthesis of 5-Benzylamino and 5-Alkylamino-substituted Pyrimidoquinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity

Kesatebrhan Haile Asressu, Jeffery L. Smith, Rebekah J. Dickmander…·Timothy Mark Willson

The paper synthesizes pyrimidoquinoline derivatives as CSNK2A inhibitors with antiviral activity, finding that certain substituents improve potency while maintaining solubility.

4 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky