John D. Sears

This paper develops a computational pipeline to identify conserved antiviral target sites in alphaviruses using AI-driven methods, validating potential drug targets through mutagenesis.

The paper describes the enantioselective resolution of a chemical probe targeting CHIKV nsP2 helicase, showing potent antiviral activity for one enantiomer and low activity for the other.

This study shows RNA ribosylation inhibits translation, decreases RNA stability, and activates antiviral immune responses in mammalian cells during chikungunya virus infection.

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

This paper identifies and optimizes oxaspiropiperidine inhibitors targeting nsP2hel, showing nanomolar antiviral activity against multiple alphaviruses.

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

The paper identifies potent covalent inhibitors of Chikungunya nsP2 protease and establishes structure-activity relationships to guide inhibitor design.

This study examines the effects of 2-deoxyglucose on gene expression across nine tissues in mice, identifying tissue-specific changes in metabolic and immunological pathways.