Author

Kouki Nishikawa

Tokyo University of Agriculture and TechnologyORCID 0000-0003-4829-440XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

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Kotaro TanakaiD· 1 shared Naotaka TsutsumiiD· 1 shared Yoshinori FujiyoshiiD· 1 shared Yuki ShiimuraiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperBiophysics

Kotaro TanakaORCID

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1 paper

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BiophysicsProceedings of the National Academy of SciencesPeer-reviewedApr 29, 2026

Structural Insights into Biased Signaling at Chemokine Receptor CCR7

Kotaro Tanaka, Kouki Nishikawa, Yuki Shiimura…·Naotaka Tsutsumi

This paper presents cryo-EM structures of CCR7 with CCL19 and CCL21, revealing distinct binding modes and dynamic receptor conformations that underlie biased agonism and differential signaling outcomes.

2 citations

humanstructural biology

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