Author

Yuki Shiimura

Kurume UniversityORCID 0000-0002-9752-7399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Barnali Paul· 1 shared Brian K. KobilkaiD· 1 shared Chunlai CheniD· 1 shared Elizabeth White· 1 shared Evan S. O’BrieniD· 1 shared John M. StreicheriD· 1 shared John R. TraynoriD· 1 shared Junzheng WangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Barnali Paul

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2 papers

Recent·Most cited

Structural Insights into Biased Signaling at Chemokine Receptor CCR7

Kotaro Tanaka, Kouki Nishikawa, Yuki Shiimura, Yoshinori Fujiyoshi, Naotaka Tsutsumi

This paper presents cryo-EM structures of CCR7 with CCL19 and CCL21, revealing distinct binding modes and dynamic receptor conformations that underlie biased agonism and differential signaling outcomes.

Proceedings of the National Academy of Sciences · Apr 29, 2026Peer-reviewedBiophysics

Discovery and dynamic pharmacology of μ-opioid receptor positive allosteric modulators

Evan S. O’Brien, Junzheng Wang, Parthasaradhireddy Tanguturi, Mengchu Li, Elizabeth White, Yuki Shiimura, Barnali Paul, Kevin Appourchaux, Kaavya Krishna Kumar, Weijiao Huang, Susruta Majumdar, John R. Traynor, John M. Streicher, Chunlai Chen, Brian K. Kobilka

This study discovers μ-opioid receptor positive allosteric modulators (PAMs) and investigates their dynamic mechanism of action to enhance opioid agonist activity while reducing side effects.

bioRxiv · Feb 21, 2026 · PreprintBiophysics