Devesha Hrishikesh Kulkarni

Kinetics of local C3 production orchestrates neutrophil recruitment in lung injury

This study shows lung-derived C3 initiates neutrophil recruitment in pneumonia before systemic C3, highlighting local complement's role in mucosal immunity.

Mucosally sourced complement factor B modulates the host response to colitis

This study shows that locally produced complement factor B in the gut reduces colitis, highlighting its role in mucosal immunity.

Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation.

This study identifies a genetic variant linked to impaired complement regulation that worsens chronic lung allograft dysfunction-free survival by promoting B cell activation and donor-specific antibodies.