Christoph Kirst

The paper shows ECM proteolysis, specifically via MMP14 and brevican, maintains dynamic synapse plasticity during brain development in zebrafish and human iPSC-derived cultures.

This paper introduces a method to track multiple animals in social interactions with high accuracy and minimal manual effort by using bidirectional segmentation with object-level memory.

The paper shows that local neurotransmitter inputs drive widespread astrocyte calcium responses and propagative events that gate future network activity.

The paper shows that while dmPFC and OFC encode similar task elements, their neural coding reliability differs, supporting distinct cognitive functions.

The paper identifies and mitigates bias in neural data models by resolving non-identifiability, showing that coupling is overestimated and tuning is underestimated in common methods.

The paper shows that WNT signaling memory enables ACTIVIN to act as a morphogen in human gastruloids by allowing graded responses to ACTIVIN without altering SMAD2 dynamics.

The paper shows GABA modulates action potential dynamics through a universal mechanism, confirmed by experiments and modeling in different neurons.

This paper identifies a universal sequence of dynamic transitions in neuronal excitability controlled by synaptic activity and demonstrates its implications for network synchronization and information processing.