Anna Victoria Molofsky

The paper identifies aggrecan as an extracellular matrix protein that stabilizes fear memories by altering neuronal excitability in the hippocampal dentate gyrus.

The paper develops a genetically encoded reporter to detect IFN responses in brain and peripheral tissues, revealing coordinated responses in neurons and non-neuronal cells across various conditions.

The paper identifies IAV-driven fibroblast states and shows that loss of TGFβ signaling enhances immuno-modulatory fibroblasts, supporting T2-Tregs to improve lung outcomes.

The paper shows ECM proteolysis, specifically via MMP14 and brevican, maintains dynamic synapse plasticity during brain development in zebrafish and human iPSC-derived cultures.

This study identifies GM-CSF as a key mediator of vertebral bone marrow emergency myelopoiesis in neuropathic pain, linking meningeal immunity to pain pathogenesis.

NOVA is an R-package for analyzing MEA data, offering dimensionality reduction, clustering, and trajectory mapping, revealing network burst duration as a key activity metric.

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

The paper shows type 1 lymphocytes produce interferon-γ in the thalamus after brain injury, reducing seizure susceptibility by limiting neural hyperexcitability.

This study shows that microglial cathepsin B is essential for efficient neuronal efferocytosis during brain development, preventing apoptotic cell accumulation and ensuring proper neural circuit formation.

This study shows that group 2 innate lymphoid cells (ILC2s) and their cytokine IL-13 promote inhibitory synapse development and adult social behavior.

This study identifies a Type I interferon-responsive microglial subset that engulfs neurons during brain development and shows its role in shaping cortical structure and behavior.

The paper identifies distinct microglial subsets in zebrafish brains that perform different phagocytic functions using single-cell RNA sequencing and spatial analysis.

This study identifies IL-33's role in microglial phagocytosis and its impact on synaptic refinement and seizure susceptibility in the developing brain.

The paper identifies core transcriptional features of human CNS cell classes by analyzing variation in intact tissue samples and shows species-specific differences in astrocyte biology.