Author

Azadeh Paksa

Pfizer (United States)ORCID 0000-0003-4871-1349Unclaimed ORCID profile · follow to get notified of new preprints

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Azadeh Paksa1 paper · Harvard University

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Molecular Biology· 1

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Approach:experimental assay· 1 Organism:human· 1

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Alicia SolórzanoiD· 1 shared Chong WangiD· 1 shared Javier F. Chaparro‐RiggersiD· 1 shared Lara F. Tshering· 1 shared Laura LiniD· 1 shared Qing XiangiD· 1 shared Sharmistha Kundu· 1 shared

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Molecular BiologybioRxivPreprintJun 13, 2025

Self-amplifying mRNA expression is governed by mitochondrial machinery and ACSL4

Lara F. Tshering, Chong Wang, Qing Xiang…·Azadeh Paksa

The paper identifies mitochondrial function and ACSL4 as key regulators of self-amplifying mRNA (saRNA) expression, showing that modulating ACSL4 improves saRNA expression across cell types.

DOI 10.1101/2025.06.13.659366

humanexperimental assay

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