Author

Alicia Solórzano

Pfizer (United States)ORCID 0000-0003-0072-3463Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:multiome· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Adele XuiD· 1 shared Andrew M. WatkinsiD· 1 shared Azadeh PaksaiD· 1 shared Bojan Tunguz· 1 shared Chong WangiD· 1 shared Christian A. ChoeiD· 1 shared Craig H. KerriD· 1 shared Daphna RothschildiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Adele XuORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJun 13, 2025

Self-amplifying mRNA expression is governed by mitochondrial machinery and ACSL4

Lara F. Tshering, Chong Wang, Qing Xiang…·Azadeh Paksa

The paper identifies mitochondrial function and ACSL4 as key regulators of self-amplifying mRNA (saRNA) expression, showing that modulating ACSL4 improves saRNA expression across cell types.

DOI 10.1101/2025.06.13.659366

humanexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedMar 22, 2022

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

Kathrin Leppek, Gun Woo Byeon, Wipapat Kladwang…·Rhiju Das

This study develops PERSIST-seq and In-line-seq to optimize mRNA stability and translation, finding that in-cell stability is more critical than ribosome load for protein output.

400 citationstop 1%

humanmultiome

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