David Garth Fernig

The potent anti-influenza virus activity of FluPep is mediated by interactions with cellular anionic polysaccharides

This study shows FluPep, an anti-influenza peptide, binds to heparan sulfate and sialic acid on cells, preventing viral infection, and engineered versions enhance its potency.

Topical Formulation of Repurposed FDA-Approved Compounds Inhibits Pseudomonas aeruginosa ExoU and Improves Corneal Infection Outcomes

This study identifies FDA-approved compounds that inhibit ExoU, a virulence factor in Pseudomonas aeruginosa, and shows their efficacy in reducing corneal infection severity in multiple models.

FLEX: A heparin-binding fusion partner engineered from fibroblast growth factor 1 to enhance protein expression, solubility and purity

This paper introduces FLEX, a fusion tag derived from FGF1 that enhances protein expression, solubility, and purity across different systems.

Concentration- and time-dependence of phosphorylation events stimulated by fibroblast growth factor-4 (FGF-4) in Rama 27 fibroblasts

This study examines how FGF-4 concentration and time affect phosphorylation of FRS2, MAPK1, and MAPK3 in Rama 27 fibroblasts, revealing oscillatory and bell-shaped responses at different concentrations.

Stable topical application of antimicrobials using plumbing rings in an ex vivo porcine corneal infection model

This paper introduces an ex vivo porcine corneal infection model using plumbing rings to improve antimicrobial application and assess its efficacy against Pseudomonas aeruginosa.