Joanne L. Fothergill

Engineering the Pseudomonas aeruginosa virus-isolation host viPAO1 reveals how host genetic barriers shape recoverable phage diversity

The paper shows that removing genetic barriers from Pseudomonas aeruginosa hosts increases the diversity of recoverable phages, leading to the isolation of 69 new phages from clinical isolates.

Topical Formulation of Repurposed FDA-Approved Compounds Inhibits Pseudomonas aeruginosa ExoU and Improves Corneal Infection Outcomes

This study identifies FDA-approved compounds that inhibit ExoU, a virulence factor in Pseudomonas aeruginosa, and shows their efficacy in reducing corneal infection severity in multiple models.

Real-time label-free exploration of the dynamics and interactions of bacteriophages

This paper introduces a label-free method to monitor bacteriophage dynamics and interactions using caustics in conventional microscopy, demonstrating feasibility with three phage strains.

Multiple ecological and evolutionary mechanisms drive treatment-induced antibiotic resistance

This study analyzes antibiotic resistance emergence in Pseudomonas aeruginosa during treatment, finding that pre-existing resistance and ecological dynamics drive resistance development.

Co-infection with Streptococcus and Rothia spp. drives prophage dynamics in Pseudomonas aeruginosa in an artificial sputum model

This study shows co-infection with Streptococcus and Rothia spp. reduces prophage gene expression and free phage levels in Pseudomonas aeruginosa in an artificial sputum model.

Defence systems drive accessory genome interactions in Pseudomonas aeruginosa.

The paper analyzes defence system interactions in Pseudomonas aeruginosa genomes to understand their role in shaping accessory genome dynamics and ecological patterns.

Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages

The paper shows CRISPR immunity in Pseudomonas aeruginosa varies in fitness benefit against virulent phages, depending on the likelihood of evolving receptor-based resistance through spontaneous mutations.

Sputum Proteomics reveals unique signatures linked to key outcomes in cystic fibrosis trials.

This study identifies sputum proteomic signatures linked to FEV1 and QoL changes in cystic fibrosis trials, revealing distinct physiological mechanisms.

Sex Hormones Alter Pseudomonas aeruginosa Iron Acquisition and Virulence Factors

This study investigates how sex hormones affect Pseudomonas aeruginosa iron acquisition and virulence in different media, finding hormone-specific changes in protein abundance and virulence pathways.

Global genomic diversity of Pseudomonas aeruginosa in bronchiectasis

The paper analyzes the genomic diversity of Pseudomonas aeruginosa in bronchiectasis, revealing distinct evolutionary patterns compared to cystic fibrosis and highlighting antimicrobial resistance mechanisms.