This study shows that ARHGAP11B is necessary and sufficient for maintaining elevated basal progenitor levels in human cerebral organoids compared to chimpanzees.

bioRxiv · Oct 1, 2020 · PreprintDevelopmental Biology

YAP activity is necessary and sufficient for basal progenitor abundance and proliferation in the developing neocortex

Milos Kostic, Judith T.M.L. Paridaen, Katherine R. Long, Nereo Kalebic, Barbara Langen, Nannette Grübling, Pauline Wimberger, Hiroshi Kawasaki, Takashi Namba, Wieland Β. Huttner

This study shows YAP activity is necessary and sufficient for basal progenitor proliferation and abundance in the developing neocortex, linking it to neocortical expansion during evolution.

Cell Reports · Apr 1, 2019Peer-reviewedNeuroscience

Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

Nereo Kalebic, Carlotta Gilardi, Mareike Albert, Takashi Namba, Katherine R. Long, Milos Kostic, Barbara Langen, Wieland Β. Huttner

This study shows that human-specific ARHGAP11B increases proliferative basal radial glia and expands the neocortex in developing ferrets.

eLife · Nov 28, 2018Peer-reviewedNeuroscience