Wieland Β. Huttner

The paper uses cerebral organoids from patients with actin mutations to show that altered cleavage plane orientation in ventricular zone progenitors leads to microcephaly.

This study investigates the role of CHD3 in human brain development using genetically modified organoids, finding it regulates synaptic development genes without affecting early neurogenesis.

This study introduces modern human-specific amino acid substitutions into mice and human brain organoids, showing improved chromosome segregation fidelity in modern humans compared to Neandertals.

The paper shows H3K9ac increases basal progenitor proliferation and neocortex size by upregulating TRNP1 in evolution.

This study shows that HCN-channel dysfunction in neural progenitors causes microcephaly by disrupting cell cycle progression and proliferation in mice.

This study shows that ARHGAP11B is necessary and sufficient for maintaining elevated basal progenitor levels in human cerebral organoids compared to chimpanzees.

This study shows Sox9 regulates basal progenitor proliferation and gliogenesis in the developing neocortex through ECM induction and integrin signaling.

This study uses single-cell genomics to compare brain development in humans, chimpanzees, and macaques, identifying human-specific gene regulatory features.

The paper introduces a robotic platform for automated microinjection into single cells in intact tissue, significantly increasing throughput and yield compared to manual methods.

This study shows YAP activity is necessary and sufficient for basal progenitor proliferation and abundance in the developing neocortex, linking it to neocortical expansion during evolution.

This study shows that human-specific ARHGAP11B increases proliferative basal radial glia and expands the neocortex in developing ferrets.

The paper identifies human-specific genes preferentially expressed in fetal neocortex progenitors and shows they have distinct cell-type specificity compared to ancestral paralogs.