Anthony Gavalas

This study shows that the SOS1-RAS inhibitor BI-3406 promotes β-cell proliferation and reverses diabetic hyperglycemia in mice.

This paper generates and validates hES cell reporter lines to monitor islet-like cluster differentiation and maturation, finding that N21 supplement improves monohormonal β-cell numbers.

This study identifies signaling pathways that enable the unlimited expansion of human pancreatic progenitors in defined conditions, leading to efficient and reproducible cell production for diabetes research and therapies.

This study investigates the role of Hoxb1 in regulating cardiac progenitor cell patterning and differentiation, showing its negative regulation of posterior SHF differentiation and its impact on congenital heart defects.