Author

Tobey J. MacDonald

Emory UniversityORCID 0000-0003-4918-1300Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Franklin ChieniD· 2 shared Jose E. Velazquez VegaiD· 2 shared Anshu MalhotraiD· 1 shared Anthony J. KimiD· 1 shared Anton V. BryksiniD· 1 shared Chanel SchroffiD· 1 shared Chetan BettegowdaiD· 1 shared Chulyong KimiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Franklin ChienORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologyJCO Precision OncologyPeer-reviewedOct 1, 2026

Medulloblastoma Spatial Transcriptomics Reveals Tumor Microenvironment Heterogeneity with High-Density Progenitor Cell Regions Correlating with High-Risk Disease

Franklin Chien, Marina E. Michaud, Mojtaba Bakhtiari…·Manoj K. Bhasin

This study uses spatial transcriptomics to analyze medulloblastoma tumor microenvironments, identifying high-risk features and spatial patterns linked to relapse.

6 citationstop 1%

humanspatial transcriptomics

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Cancer BiologyNeuro-OncologyPeer-reviewedMar 6, 2026

ONC206 demonstrates potent anti-tumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma

Theophilos Tzaridis, Jingbo Liu, Franklin Chien…·T. MacDonald

This study shows ONC206 effectively kills medulloblastoma cells and extends survival in mouse models, supporting its potential as a new treatment for high-risk medulloblastoma.

3 citationstop 1%

mousehuman

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BioengineeringbioRxivPreprintMay 1, 2025

Data-driven feedback augments ultrasound nanotheranostics in brain tumors

Hohyun Lee, Victor Menezes, Shiyan Zeng…·Costas Arvanitis

This study uses machine learning to enhance focused ultrasound for BBB opening, improving nanoparticle delivery and tumor DNA detection in brain tumors.

DOI 10.1101/2025.05.01.651328

mouserat

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