Igor E. Brodsky

The paper creates a single-cell and spatial transcriptomics atlas of the ileum during diverse infections, revealing novel cell states and immune responses.

This study shows that the polysaccharide portion of LPS, not just lipid A acylation, is critical for Casp11 inflammasome activation and pyroptosis.

The paper shows replicating Salmonella triggers TNF- and caspase-8-driven apoptosis via TLR4 and SPI-2, distinct from non-replicating Salmonella-induced pyroptosis.

This study shows that small bacterial founder populations independently colonize intestinal and systemic tissues during Yersinia infection, with TNF signaling restricting dissemination.

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

The paper develops a new peptide-based inhibitor targeting caspase-8 and reveals shared specificities between inflammatory and apoptotic caspases.

This study shows TLR priming increases NLRC4 expression in murine macrophages, enabling detection of immunoevasive NAIP ligands, while human macrophages lack this response.