Karthik Hullahalli

This paper develops a simulation-based metric to accurately interpret bacterial dissemination by distinguishing true dissemination from barcode confounding in barcoded bacteria studies.

This paper shows that IscR, an iron-sulfur cluster sensor, regulates virulence gene expression in Yersinia pseudotuberculosis by responding to iron and oxygen levels, with mutations altering infection dynamics.

This study shows that small bacterial founder populations independently colonize intestinal and systemic tissues during Yersinia infection, with TNF signaling restricting dissemination.

This study models Pseudomonas aeruginosa gastrointestinal carriage in mice using vancomycin pretreatment and identifies the stomach as a major barrier to colonization.

InducTn-seq improves transposon mutagenesis by enabling temporal control of transposition, generating diverse mutants and quantifying gene fitness across essential and non-essential genes.

This study shows that lethal Streptococcus suis serotype 2 infection in mice is driven by widened lymph node bottlenecks and the virulence factor suilysin, leading to systemic bacterial spread.

This study tracks Klebsiella pneumoniae dissemination from the lung using barcoding, revealing two distinct patterns of bacterial spread and their associated host and bacterial factors.

This paper quantifies Salmonella enterica serovar Typhimurium population dynamics in mice using a barcoded library, revealing bottlenecks, compartmentalization, and dissemination patterns.