Debasish Sinha

This paper identifies an AKT1-TERT-FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE cells under stress.

This study identifies a diet-induced metabolic-immune axis linking gut microbiome changes to systemic immune aging and retinal degeneration in mice and AMD patients.

The paper identifies βA3/A1-crystallin as an epigenetic regulator of HDAC3 in RPE cells, showing it enhances HDAC3 activity through CK2 interaction and InsP6 regulation, linking it to AMD pathogenesis.

This study shows cigarette smoke and aging induce degenerative heterogeneity in RPE cells through distinct epigenetic changes, with young RPE showing compensatory responses not seen in aged RPE.

The paper investigates immune alterations in early AMD, finding elevated NK cell activity and reduced adenosine, suggesting immune imbalance drives disease progression.

This study identifies global decreases in chromatin accessibility in AMD patients, linking epigenetic changes to disease progression and suggesting HDAC11 as a potential therapeutic target.