Author

David R. F. Leach

University of EdinburghORCID 0000-0003-4964-6913Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 2 Organism:E. coli· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Alexei A. AraviniD· 1 shared Alina G. KudinovaiD· 1 shared Anastasiya D. OguienkoiD· 1 shared Andrey V. KulbachinskiyiD· 1 shared Anton KuzmenkoiD· 1 shared Daria EsyuninaiD· 1 shared Denis YudiniD· 1 shared Dinh To Le· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperMolecular Biology

Alexei A. AravinORCID

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3 papers

Recent·Most cited

GeneticsNucleic Acids ResearchPeer-reviewedNov 11, 2024

Degradation and Stable Maintenance of AAV Inverted Terminal Repeats in E. coli

Marco T. Radukic, Dinh To Le, Timo Krassuski…·Kristian Mark Müller

The paper identifies conditions that stabilize AAV inverted terminal repeats (ITRs) in E. coli, improving rAAV yield and purity.

11 citations

E. colilong-read sequencing

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMar 1, 2020

pAgo-induced DNA interference protects bacteria from invader DNA

Anton Kuzmenko, Anastasiya D. Oguienko, Daria Esyunina…·Andrey V. Kulbachinskiy

This study shows that the bacterial Argonaute nuclease CbAgo uses DNA interference to cleave multicopy genetic elements like plasmids and transposons by generating small DNA guides through cooperation with repair machinery.

3 citations

bacteria (other)DNA methylation

𝕏 PostBluesky

GeneticsPLoS GeneticsPeer-reviewedJan 2, 2020

DNA Double Strand Break Repair in E. coli Perturbs Cell Division and Chromosome Dynamics

Martin A. White, Elise Darmon, Manuel A. Lopez-Vernaza, David R. F. Leach

The paper shows that DNA double-strand break repair in E. coli delays cell division and chromosome segregation without affecting genome replication time or average cell size at initiation.

8 citations

E. coliDNA methylation

𝕏 PostBluesky