Author

Denis Yudin

Kurchatov InstituteORCID 0000-0002-4103-0543Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 4 Approach:experimental assay· 4 Organism:bacteria (other)· 3 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alexei A. AraviniD· 4 shared Andrey V. KulbachinskiyiD· 4 shared Anton KuzmenkoiD· 4 shared Sergei S. RyazanskyiD· 3 shared Aleksei AgapoviD· 2 shared Daria EsyuninaiD· 2 shared Alina G. KudinovaiD· 1 shared Anastasiya D. OguienkoiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersMolecular Biology

Alexei A. AravinORCID

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4 papers

Recent·Most cited

Bacterial Argonaute nucleases reveal different modes of DNA targeting in vitro and in vivo

Lidiya Lisitskaya, Ekaterina Kropocheva, Aleksei Agapov, Maria A Prostova, Vladimir Panteleev, Denis Yudin, Sergei S. Ryazansky, Anton Kuzmenko, Alexei A. Aravin, Daria Esyunina, Andrey V. Kulbachinskiy

This study investigates the DNA targeting mechanisms of five bacterial Argonaute proteins in vitro and in vivo, revealing their ability to cleave DNA and defend against bacteriophages.

Nucleic Acids Research · Apr 24, 2023Peer-reviewedMolecular Biology

Bacterial Argonaute proteins aid cell division in the presence of topoisomerase inhibitors in Escherichia coli

Anna Olina, Aleksei Agapov, Denis Yudin, Anton Kuzmenko, Alexei A. Aravin, Andrey V. Kulbachinskiy

The paper shows that bacterial Argonaute proteins assist in cell division in E. coli under topoisomerase inhibitor stress by processing DNA replication termination sites.

bioRxiv · Sep 13, 2022 · PreprintMolecular Biology

pAgo-induced DNA interference protects bacteria from invader DNA

Anton Kuzmenko, Anastasiya D. Oguienko, Daria Esyunina, Denis Yudin, Petrova Ma, Alina G. Kudinova, Olga Maslova, Maria Ninova, Sergei S. Ryazansky, David R. F. Leach, Alexei A. Aravin, Andrey V. Kulbachinskiy

This study shows that the bacterial Argonaute nuclease CbAgo uses DNA interference to cleave multicopy genetic elements like plasmids and transposons by generating small DNA guides through cooperation with repair machinery.

bioRxiv · Mar 1, 2020 · PreprintMolecular Biology

Programmable DNA cleavage by Ago nucleases from mesophilic bacteria Clostridium butyricum and Limnothrix rosea

Anton Kuzmenko, Denis Yudin, Sergei S. Ryazansky, Andrey V. Kulbachinskiy, Alexei A. Aravin

This study identifies two mesophilic prokaryotic Argonautes that function as DNA-guided DNA nucleases at physiological temperatures, expanding their potential for genomic applications.

Nucleic Acids Research · Apr 30, 2019Peer-reviewedMolecular Biology