pAgo-induced DNA interference protects bacteria from invader DNA
Anton Kuzmenko, Anastasiya D. Oguienko, Daria Esyunina, Denis Yudin, Petrova Ma, Alina G. Kudinova, Olga Maslova, Maria Ninova, Sergei S. Ryazansky, David R. F. Leach, Alexei A. Aravin, Andrey V. Kulbachinskiy
This study shows that the bacterial Argonaute nuclease CbAgo uses DNA interference to cleave multicopy genetic elements like plasmids and transposons by generating small DNA guides through cooperation with repair machinery.
bioRxiv · Mar 1, 2020 · PreprintMolecular Biology