Author
Indiana University IndianapolisORCID 0000-0003-4966-1996Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Angelia D. Lockett, Pontian Adogamhe, Aaron Snow…·Roberto F. Machado
This study shows that Nampt activates the mitochondrial unfolded protein response to enhance pulmonary arterial endothelial cell proliferation in PAH.
P. De La Cruz, Angelia D. Lockett, Marta Teixeira Gomes…·Roberto F. Machado
This study shows that pulmonary hypertension increases microglia and astrocyte density, reduces neuronal density, and causes TDP-43 mislocalization in both rat and human brain tissue.
Angelia D. Lockett, Aaron Snow, Pontian Adogamhe…·Roberto F. Machado
This study shows that the Sphk1/S1P/S1P2 signaling axis promotes PASMC proliferation in PAH via activation of the mitochondrial unfolded protein response (UPRmt), which can be inhibited to reduce vascular remodeling.
P. De La Cruz, Marta Teixeira Gomes, Angelia D. Lockett…·Roberto F. Machado
The paper shows partial Wwox loss of function in mice worsens sepsis severity and neuroinflammation.